HIP/PAP prevents excitotoxic neuronal death and promotes plasticity

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HIP/PAP prevents excitotoxic neuronal death and promotes plasticity

OBJECTIVES Excitotoxicity plays a significant role in the pathogenesis of perinatal brain injuries. Among the consequences of excessive activation of the N-methyl-d-aspartate (NMDA)-type glutamate are oxidative stress caused by free radical release from damaged mitochondria, neuronal death and subsequent loss of connectivity. Drugs that could protect nervous tissue and support regeneration are ...

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ژورنال

عنوان ژورنال: Annals of Clinical and Translational Neurology

سال: 2014

ISSN: 2328-9503

DOI: 10.1002/acn3.127